Vyleesi Injection in Malaysia: Women’s Low Libido & Men’s Experimental Use

2 Dec 2025

Vyleesi Injection in Malaysia: What Women and Men Should Know

Imagine a tiny self-injection that could help restore sexual desire — on your terms. That’s the promise of Vyleesi (bremelanotide), a drug officially approved in the U.S. for women with low libido. But what about men? Let’s dive into the details.

For Women: The Official Use

Vyleesi is approved for premenopausal women diagnosed with Hypoactive Sexual Desire Disorder (HSDD) — a medical term for low sexual desire that causes distress.

How it works: Vyleesi is a melanocortin receptor agonist, meaning it acts on certain brain receptors linked to sexual desire rather than hormones or blood flow.
Usage: Self-injected under the skin in the abdomen or thigh, about 45 minutes before sexual activity.
Frequency: Maximum of 8 doses per month, with at least 24 hours between doses.
Effects: Many women report increased interest in intimacy and reduced distress over low desire.
Side effects: Nausea, flushing, headache, dizziness, injection-site reactions, temporary increases in blood pressure, and in some cases, skin darkening (hyperpigmentation). Women with uncontrolled hypertension or cardiovascular disease should avoid Vyleesi.
Availability in Malaysia: Vyleesi is not yet registered locally, so it cannot be legally obtained from clinics or pharmacies. Importing it independently carries legal and safety risks.

For Men: Experimental, Off-Label Use

Though Vyleesi is not approved for men, some clinicians and researchers have explored its use for men experiencing:

Erectile dysfunction
Low sexual desire
Performance anxiety

Preliminary findings: Small studies and anecdotal reports suggest some men may experience:

Improved erectile function
Increased sexual interest and satisfaction
Ability to achieve additional erections up to 18–24 hours after injection

Important caveats:

Use in men is off-label and experimental.
Safety and efficacy for male sexual dysfunction are not fully established.
Official guidelines warn against using Vyleesi for “enhancing sexual performance” in men.

For Malaysian men, any consideration of Vyleesi should be under strict medical supervision, understanding the uncertain benefits and risks.

Alternative Approaches in Malaysia

Since Vyleesi is not officially available in Malaysia for women — and is experimental for men — safer, legal alternatives include:

Lifestyle improvements: Exercise, stress management, sleep, and emotional well-being.
Therapy and counseling: For relationship issues, sexual anxiety, or emotional barriers to intimacy.
Medical consultation: Hormone evaluation, reviewing medications, or other approved treatments.

These approaches are proven, safe, and can enhance sexual desire without the risks of unapproved medications.

Takeaway

For women: Vyleesi is a novel, on-demand option for restoring sexual desire, but it is not yet accessible in Malaysia.

For men: Experimental evidence suggests potential benefits, but it is off-label and unapproved, so caution is essential.

In both cases, the most effective path is professional guidance combined with lifestyle or therapeutic support. Vyleesi may offer a glimpse into the future of sexual wellness, but for now, awareness, education, and safe, evidence-based practices remain the key in Malaysia.