Vyleesi Injection: What Singapore Women Should Know About This “Desire” Treatment

2 Dec 2025

Meet Vyleesi: Your “On‑Demand Desire Reset”

Imagine a tiny injection, tucked away in a discreet pen — something you use only when you want to. That’s Vyleesi. Officially, Vyleesi (generic name bremelanotide) is the first and only as‑needed treatment approved by the U.S. Food and Drug Administration (FDA) for certain women with “low libido.”

Vyleesi is for premenopausal women who once had a healthy sexual desire but now — for no clear physical or relationship reason — find that desire slipping. It’s meant for “generalized, acquired” low libido (meaning: low sexual desire across different situations/partners, and not due to illness or medication).

Here’s how the “magic potion” version of Vyleesi goes in marketing:

You inject it yourself, subcutaneously (just under the skin) in the abdomen or thigh.
You do it about 45 minutes before anticipated intimacy.
It’s “only when you choose.” No daily pills, no constant medication reminders — just when you want.
Reported effect: many women in clinical trials said they felt more interest in sex and — importantly — less distress or frustration over their lack of desire.

In a world where libido — for women especially — has often been brushed under the carpet or treated as “just in your head,” Vyleesi comes across like a bold new invitation: control your desire on your own terms.

The Science Behind the Shot — How It’s Supposed to Work

We don’t have a love‑potion or a guaranteed “turn me on” ray — but researchers believe Vyleesi works on a chemical level in the brain. Bremelanotide is a melanocortin receptor agonist. That means it binds to certain receptors (melanocortin receptors) in the brain — receptors that are part of the neurological signaling pathways involved in sexual desire.

In some women with low libido (for no other diagnosable reason), the balance of neurotransmitters — the brain’s chemical messengers — may be off. Vyleesi aims to rebalance or compensate, essentially giving those signals a “boost.”

The idea is not to “force passion,” but to restore desire to a level where sexual interest feels natural again. For some women in clinical studies, this translated into modest but meaningful improvements — a real change in how they felt about intimacy, their self‑esteem, and their relationship.

But it’s important to be realistic: it is not a guarantee. The effects vary. As one expert quoted when Vyleesi launched said, there’s no magic wand — but for some women with medically diagnosable low libido, the injection can represent a real chance.

What About Singapore — Is Vyleesi Available There?

Here’s where things get … complicated (and somewhat sobering).

Despite the buzz around “female Viagra” or libido‑boosting drugs, as of 2025 Vyleesi is not registered for women in Singapore — according to sources that track sexual‑health medication availability.

In other words: you cannot legally get a prescription for Vyleesi in a Singapore clinic or pharmacy.

That means any claim of having “Vyleesi for women” in Singapore should be met with skepticism — because buying or importing unregistered prescription medications can pose legal risks and safety hazards.

As with many “female sexual‑health innovations,” there’s interest; but regulation and cultural norms (plus legitimate safety/efficacy scrutiny) are slowing things down.

Side Effects & What You Should Know Before Imagining the Fairy‑Tale

Because Vyleesi works on the brain and the cardiovascular system — and because it’s a real medicine — there are real potential side effects. Some are mild; some are serious.

Common / mild-ish effects:

Nausea (especially in the first dose).
Flushing (feeling hot, warm flush).
Headache, injection‑site reactions (pain, swelling where you injected), possibly vomiting or dizziness.

More serious / caution‑required effects:

Temporary increase in blood pressure and decrease in heart rate after injection. For someone with uncontrolled hypertension or known cardiovascular disease, that’s a big red flag.
Skin changes: in some people — especially those with darker skin tones — the drug can cause focal hyperpigmentation (darkening of skin in areas like face, gums, breasts). This change may be persistent, even after stopping the drug.
Because Vyleesi is not supposed to treat pain, performance issues, or relational problems — but specifically a certain type of “low desire” — it’s ineffective (or inappropriate) for many other kinds of sexual or relationship struggles.

Additionally, some clinicians caution that while Vyleesi can help “reset desire,” desire itself is complex. It often involves relationship dynamics, stress, hormones, emotions — and not always something a drug can “fix.”

In fact, several experts say medication should not be the first line of treatment. Lifestyle, therapy or counseling, hormone evaluation — these often deserve attention first.

The Big Picture: Why Vyleesi Matters — and Why It’s Not a Fairy Tale

What Vyleesi represents:

A step toward recognizing that low sexual desire in women is not shameful or imaginary — it can be a real basis for distress, for some people.
A treatment option that gives women autonomy: you decide when, you decide if. You don’t have to take a daily pill; you don’t have to “fix” libido before it even matters.
A recognition that sexuality isn’t always just physical — sometimes the “lack of desire” has roots in brain chemistry.

Why it still isn’t simple:

The drug does not help everyone. Some may see benefits; others may not notice any difference or may get side effects.
Medical, legal, and regulatory barriers — especially in countries outside the U.S. (like Singapore) — mean that “having it” isn’t just a matter of wanting it.
Sexual desire is complicated. For many people, it depends on emotional, relational, hormonal, psychological, and social factors — far beyond what a drug can touch.

So, If You’re in Singapore — What Should You Do Instead of Dreaming of Vyleesi?

Since Vyleesi isn’t legally available in Singapore, and because any importation or “underground” sourcing can be risky, here are some safer and more realistic approaches:

Talk to a qualified women’s‑health doctor or gynecologist if you’re feeling distress about low desire. They can help you rule out hormone imbalances, side‑effects of other meds, or underlying medical issues.
Consider counseling or therapy (alone or with your partner). Sometimes the root of low libido is stress, relationship dynamics, life changes — things that a conversation can help.
Lifestyle changes: sleep, stress reduction, physical exercise, open communication with partner, emotional intimacy — which can all positively affect libido.
Explore safer, evidence‑based options (if appropriate) under medical supervision, especially those accepted in your country’s regulatory framework.

Final Word

Vyleesi is a bold, attention‑grabbing concept — a “desire shot” rather than a daily pill, marketed as a way to reclaim sexual interest on your terms. But it’s not a magic bullet. For some women, it may help; for others, it may disappoint; and for many, it may never even be an option — especially in places like Singapore where it’s not registered.

If you — or someone you know — is struggling with low libido, the most powerful first step is a conversation with a caring, informed healthcare provider. Because sometimes the answer isn’t in a syringe — it’s in understanding, support, and care.